Allelic variation of KIR and HLA tunes the cytolytic payload and determines functional hierarchy of NK cell repertoires

The functionality of natural killer (NK) cells is tuned during education and is associated with remodeling of the lysosomal compartment. We hypothesized that genetic variation in killer cell immunoglobulin-like receptor (KIR) and HLA, which is known to influence the functional strength of NK cells,...

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Detalles Bibliográficos
Autores principales: Philippon, Camille, Tao, Sudan, Clement, Dennis, Haroun-Izquierdo, Alvaro, Kichula, Katherine M., Netskar, Herman, Brandt, Ludwig, Oei, Vincent Sheng, Kanaya, Minoru, Lanuza, Pilar Maria, Schaffer, Marie, Goodridge, Jodie P., Horowitz, Amir, Zhu, Faming, Hammer, Quirin, Sohlberg, Ebba, Majhi, Rakesh Kumar, Kveberg, Lise, Önfelt, Björn, Norman, Paul J., Malmberg, Karl-Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2023
Materias:
Immunobiology and Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10440473/
https://www.ncbi.nlm.nih.gov/pubmed/37327114
http://dx.doi.org/10.1182/bloodadvances.2023009827

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10440473/
https://www.ncbi.nlm.nih.gov/pubmed/37327114
http://dx.doi.org/10.1182/bloodadvances.2023009827

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