hGFAP-mediated GLI2 overexpression leads to early death and severe cerebellar malformations with rare tumor formation

The zinc-finger transcription factor GLI2 is frequently amplified in childhood medulloblastoma of the Sonic-hedgehog type (SHH-MB), with or without amplification of NMYC or deletion of TP53. Despite the aggressive tumor behavior, tumorigenesis is not well understood, and adequate mouse models are la...

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Detalles Bibliográficos
Autores principales: Niesen, Judith, Hermans-Borgmeyer, Irm, Krüger, Christina, Schoof, Melanie, Modemann, Franziska, Schüller, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10440564/
https://www.ncbi.nlm.nih.gov/pubmed/37608807
http://dx.doi.org/10.1016/j.isci.2023.107501

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10440564/
https://www.ncbi.nlm.nih.gov/pubmed/37608807
http://dx.doi.org/10.1016/j.isci.2023.107501

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