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hGFAP-mediated GLI2 overexpression leads to early death and severe cerebellar malformations with rare tumor formation
The zinc-finger transcription factor GLI2 is frequently amplified in childhood medulloblastoma of the Sonic-hedgehog type (SHH-MB), with or without amplification of NMYC or deletion of TP53. Despite the aggressive tumor behavior, tumorigenesis is not well understood, and adequate mouse models are la...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10440564/ https://www.ncbi.nlm.nih.gov/pubmed/37608807 http://dx.doi.org/10.1016/j.isci.2023.107501 |