Glutathionylation of pyruvate dehydrogenase complex E2 and inflammatory cytokine production during acute inflammation are magnified by mitochondrial oxidative stress

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Lipopolysaccharide (LPS) is a known inducer of inflammatory signaling which triggers generation of reactive oxygen species (ROS) and cell death in responsive cells like THP-1 promonocytes and freshly isolated human monocytes. A key LPS-responsive metabolic pivot point is the 9 MDa mitochondrial pyru...

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Detalles Bibliográficos
Autores principales: Long, David L., McCall, Charles E., Poole, Leslie B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10440583/
https://www.ncbi.nlm.nih.gov/pubmed/37566945
http://dx.doi.org/10.1016/j.redox.2023.102841

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10440583/
https://www.ncbi.nlm.nih.gov/pubmed/37566945
http://dx.doi.org/10.1016/j.redox.2023.102841

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