The dynamic process of covalent and non-covalent PARylation in the maintenance of genome integrity: a focus on PARP inhibitors

Poly(ADP-ribosylation) (PARylation) by poly(ADP-ribose) polymerases (PARPs) is a highly regulated process that consists of the covalent addition of polymers of ADP-ribose (PAR) through post-translational modifications of substrate proteins or non-covalent interactions with PAR via PAR binding domain...

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Detalles Bibliográficos
Autores principales: Beneyton, Adèle, Nonfoux, Louis, Gagné, Jean-Philippe, Rodrigue, Amélie, Kothari, Charu, Atalay, Nurgul, Hendzel, Michael J, Poirier, Guy G, Masson, Jean-Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Critical Reviews and Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10440794/
https://www.ncbi.nlm.nih.gov/pubmed/37609662
http://dx.doi.org/10.1093/narcan/zcad043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10440794/
https://www.ncbi.nlm.nih.gov/pubmed/37609662
http://dx.doi.org/10.1093/narcan/zcad043

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