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P300/SP1 complex mediating elevated METTL1 regulates CDK14 mRNA stability via internal m7G modification in CRPC

BACKGROUND: N7-methylguanosine (m7G) modification is, a more common epigenetic modification in addition to m6A modification, mainly found in mRNA capsids, mRNA interiors, transfer RNA (tRNA), pri-miRNA, and ribosomal RNA (rRNA). It has been found that m7G modifications play an important role in mRNA...

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Detalles Bibliográficos
Autores principales: Zhang, Mingpeng, Kan, Duo, Zhang, Boya, Chen, Xueqiao, Wang, Chun, Chen, Songmao, Gao, Wenlong, Yang, Zhao, Li, Yang, Chen, Yutong, Zhu, Shimiao, Wen, Simeng, Niu, Yuanjie, Shang, Zhiqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10440916/
https://www.ncbi.nlm.nih.gov/pubmed/37599359
http://dx.doi.org/10.1186/s13046-023-02777-z