Targeting sphingosine 1-phosphate receptor 3 inhibits T-cell exhaustion and regulates recruitment of proinflammatory macrophages to improve antitumor efficacy of CAR-T cells against solid tumor

BACKGROUNDS: Chimeric antigen receptor (CAR)-modified T cells (CAR-T) are limited in solid tumors due to the hostile tumor microenvironment (TME). Combination therapy could be a promising approach to overcome this obstacle. Recent studies have shown that sphingosine 1-phosphate receptor (S1PR)3 has...

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Detalles Bibliográficos
Autores principales: Gao, Ge, Liao, Weiting, Shu, Pei, Ma, Qizhi, He, Xia, Zhang, Benxia, Qin, Diyuan, Wang, Yongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441059/
https://www.ncbi.nlm.nih.gov/pubmed/37591632
http://dx.doi.org/10.1136/jitc-2022-006343

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441059/
https://www.ncbi.nlm.nih.gov/pubmed/37591632
http://dx.doi.org/10.1136/jitc-2022-006343

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