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k(L)a based scale-up cultivation of the extremophilic archaeon Sulfolobus acidocaldarius: from benchtop to pilot scale

The two major scale-up criteria in continuously stirred bioreactors are 1) constant aerated power input per volume (Pg/Vl), and 2) the volumetric O(2) mass transfer coefficient (kla). However, Pg/Vl is only influenced by the stirrer geometry, stirrer speed, aeration and working volume, while the kla...

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Detalles Bibliográficos
Autores principales: Rastädter, Kerstin, Wurm, David J., Spadiut, Oliver, Quehenberger, Julian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441222/
https://www.ncbi.nlm.nih.gov/pubmed/37609112
http://dx.doi.org/10.3389/fbioe.2023.1160012