Antigen Geometry Tunes Mast Cell Signaling Through Distinct FcεRI Aggregation and Structural Changes

Immunoreceptor tyrosine-based activation motif (ITAM)-containing Fc receptors are critical components of the innate and adaptive immune systems. FcεRI mediates the allergic response via crosslinking of IgE-bound receptors by multivalent antigens. Yet, the underlying molecular mechanisms that govern...

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Detalles Bibliográficos
Autores principales: Rinaldi, Derek A., Kanagy, William K., Kaye, Hannah C., Grattan, Rachel M., Lucero, Shayna R., Pérez, Marelessis Palomino, Wester, Michael J., Lidke, Keith A., Wilson, Bridget S., Lidke, Diane S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441289/
https://www.ncbi.nlm.nih.gov/pubmed/37609336
http://dx.doi.org/10.1101/2023.08.04.552060

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441289/
https://www.ncbi.nlm.nih.gov/pubmed/37609336
http://dx.doi.org/10.1101/2023.08.04.552060

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