Using deep long-read RNAseq in Alzheimer’s disease brain to assess clinical relevance of RNA isoform diversity

Due to alternative splicing, human protein-coding genes average over eight RNA isoforms, resulting in nearly four distinct protein coding sequences per gene. Long-read RNAseq (IsoSeq) enables more accurate quantification of isoforms, shedding light on their specific roles. To assess the clinical rel...

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Detalles Bibliográficos
Autores principales: Heberle, Bernardo Aguzzoli, Brandon, J. Anthony, Page, Madeline L., Nations, Kayla A., Dikobe, Ketsile I., White, Brendan J., Gordon, Lacey A., Fox, Grant A., Wadsworth, Mark E., Doyle, Patricia H., Fox, Edward J., Shantaraman, Anantharaman, Ryten, Mina, Goodwin, Sara, Ghiban, Elena, Wappel, Robert, Mavruk-Eskipehlivan, Senem, Miller, Justin B., Seyfried, Nicholas T., Nelson, Peter T., Fryer, John D., Ebbert, Mark T. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441303/
https://www.ncbi.nlm.nih.gov/pubmed/37609156
http://dx.doi.org/10.1101/2023.08.06.552162

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441303/
https://www.ncbi.nlm.nih.gov/pubmed/37609156
http://dx.doi.org/10.1101/2023.08.06.552162

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