Force-induced site-specific enzymatic cleavage probes reveal that serial mechanical engagement boosts T cell activation

The surface of T cells is studded with T cell receptors (TCRs) that are used to scan target cells to identify peptide-major histocompatibility complexes (pMHCs) signatures of viral infection or cancerous mutation. It is now established that the TCR-pMHC complex is highly transient and experiences me...

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Detalles Bibliográficos
Autores principales: Rogers, Jhordan, Ma, Rong, Hu, Yuesong, Salaita, Khalid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441320/
https://www.ncbi.nlm.nih.gov/pubmed/37609308
http://dx.doi.org/10.1101/2023.08.07.552310

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441320/
https://www.ncbi.nlm.nih.gov/pubmed/37609308
http://dx.doi.org/10.1101/2023.08.07.552310

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