Chemical and biophysical characterization of novel potassium channel blocker 3-fluoro-5-methylpyridin-4-amine

4-aminopyridine (4AP) is a potassium (K(+)) channel blocker used clinically to improve walking in people with multiple sclerosis (MS). 4AP binds to exposed K(+) channels in demyelinated axons, reducing the leakage of intracellular K(+) and enhancing impulse conduction. Multiple derivatives of 4AP ca...

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Detalles Bibliográficos
Autores principales: Sun, Yang, Rodríguez-Rangel, Sofia, Zhang, Lauren L., Sánchez-Rodríguez, Jorge E., Brugarolas, Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441322/
https://www.ncbi.nlm.nih.gov/pubmed/37609160
http://dx.doi.org/10.1101/2023.08.08.550404

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441322/
https://www.ncbi.nlm.nih.gov/pubmed/37609160
http://dx.doi.org/10.1101/2023.08.08.550404

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