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An Aurora kinase A-BOD1L1-PP2A B56 Axis promotes chromosome segregation fidelity

Cancer cells are often aneuploid and frequently display elevated rates of chromosome mis-segregation in a phenomenon called chromosomal instability (CIN). CIN is commonly caused by hyperstable kinetochore-microtubule (K-MT) attachments that reduces the efficiency of correction of erroneous K-MT atta...

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Detalles Bibliográficos
Autores principales: Kucharski, Thomas J., Vlasac, Irma M., Higgs, Martin R., Christensen, Brock C., Compton, Duane A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441337/
https://www.ncbi.nlm.nih.gov/pubmed/37609141
http://dx.doi.org/10.1101/2023.08.06.552174