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Structural basis of closed groove scrambling by a TMEM16 protein
Activation of Ca(2+)-dependent TMEM16 scramblases induces the externalization of phosphatidylserine, a key molecule in multiple signaling processes. Current models suggest that the TMEM16s scramble lipids by deforming the membrane near a hydrophilic groove, and that Ca(2+) dependence arises from the...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441378/ https://www.ncbi.nlm.nih.gov/pubmed/37609346 http://dx.doi.org/10.1101/2023.08.11.553029 |