Structural basis of closed groove scrambling by a TMEM16 protein

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Activation of Ca(2+)-dependent TMEM16 scramblases induces the externalization of phosphatidylserine, a key molecule in multiple signaling processes. Current models suggest that the TMEM16s scramble lipids by deforming the membrane near a hydrophilic groove, and that Ca(2+) dependence arises from the...

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Detalles Bibliográficos
Autores principales: Feng, Zhang, Alvarenga, Omar E., Accardi, Alessio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441378/
https://www.ncbi.nlm.nih.gov/pubmed/37609346
http://dx.doi.org/10.1101/2023.08.11.553029

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