The mTOR pathway genes mTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function

Brain somatic mutations in various components of the mTOR complex 1 (mTORC1) pathway have emerged as major causes of focal malformations of cortical development and intractable epilepsy. While these distinct gene mutations converge on excessive mTORC1 signaling and lead to common clinical manifestat...

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Detalles Bibliográficos
Autores principales: Nguyen, Lena H., Xu, Youfen, Nair, Maanasi, Bordey, Angelique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441381/
https://www.ncbi.nlm.nih.gov/pubmed/37609221
http://dx.doi.org/10.1101/2023.08.11.553034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441381/
https://www.ncbi.nlm.nih.gov/pubmed/37609221
http://dx.doi.org/10.1101/2023.08.11.553034

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