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The juxtamembrane linker of synaptotagmin 1 regulates Ca(2+) binding via liquid-liquid phase separation
Synaptotagmin (syt) 1, a Ca(2+) sensor for synaptic vesicle exocytosis, is thought to act in vivo as a multimer. It senses Ca(2+) via tandem C2-domains that are connected to a single transmembrane domain via a juxtamembrane linker. Here, we show that this linker segment harbors a lysine-rich, intrin...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441399/ https://www.ncbi.nlm.nih.gov/pubmed/37609296 http://dx.doi.org/10.1101/2023.08.11.551903 |