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SUMOylation of the m6A reader YTHDF2 by PIAS1 promotes viral RNA decay to restrict EBV replication

YTHDF2 is a member of the YTH protein family that binds to N6-methyladenosine (m6A)-modified RNA, regulating RNA stability and restricting viral replication, including Epstein-Barr virus (EBV). PIAS1 is an E3 SUMO ligase known as an EBV restriction factor, but its role in YTHDF2 SUMOylation remains...

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Detalles Bibliográficos
Autores principales:	Sugiokto, Febri Gunawan, Saiada, Farjana, Zhang, Kun, Li, Renfeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441406/ https://www.ncbi.nlm.nih.gov/pubmed/37609256 http://dx.doi.org/10.1101/2023.08.08.552509

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