Bacterial Shedu immune nucleases share a common enzymatic core regulated by diverse sensor domains

Prokaryotes encode diverse anti-bacteriophage immune systems, including the single-protein Shedu nuclease. Here we reveal the structural basis for activation of Bacillus cereus Shedu. In the inactive homotetramer, a key catalytic residue in Shedu’s nuclease domain is sequestered away from the cataly...

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Detalles Bibliográficos
Autores principales: Gu, Yajie, Li, Huan, Deep, Amar, Enustun, Eray, Zhang, Dapeng, Corbett, Kevin D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441436/
https://www.ncbi.nlm.nih.gov/pubmed/37609250
http://dx.doi.org/10.1101/2023.08.10.552793

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441436/
https://www.ncbi.nlm.nih.gov/pubmed/37609250
http://dx.doi.org/10.1101/2023.08.10.552793

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