A cryptic pocket in METTL3-METTL14 regulates m(6)A conversion and sensing

The nuclear METTL3-METTL14 enzyme complex transfers a methyl group from S-adenosyl-L-methionine (SAM) to the N(6) amino group of an adenosine (A) base in RNA to convert it to m(6)A and in ssDNA to 6mA. m(6)A marks are prevalent in eukaryotic mRNAs and lncRNAs and modulate their stability and fate in...

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Detalles Bibliográficos
Autores principales: Qi, Shan, Gupta, Yogesh K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441475/
https://www.ncbi.nlm.nih.gov/pubmed/37609305
http://dx.doi.org/10.21203/rs.3.rs-3150186/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441475/
https://www.ncbi.nlm.nih.gov/pubmed/37609305
http://dx.doi.org/10.21203/rs.3.rs-3150186/v1

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