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A cryptic pocket in METTL3-METTL14 regulates m(6)A conversion and sensing
The nuclear METTL3-METTL14 enzyme complex transfers a methyl group from S-adenosyl-L-methionine (SAM) to the N(6) amino group of an adenosine (A) base in RNA to convert it to m(6)A and in ssDNA to 6mA. m(6)A marks are prevalent in eukaryotic mRNAs and lncRNAs and modulate their stability and fate in...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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American Journal Experts
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441475/ https://www.ncbi.nlm.nih.gov/pubmed/37609305 http://dx.doi.org/10.21203/rs.3.rs-3150186/v1 |