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A Multi-Ancestry Polygenic Risk Score for Coronary Heart Disease Based on an Ancestrally Diverse Genome-Wide Association Study and Population-Specific Optimization
BACKGROUND: Predictive performance of polygenic risk scores (PRS) varies across populations. To facilitate equitable clinical use, we developed PRS for coronary heart disease (PRS(CHD)) for 5 genetic ancestry groups. METHODS: We derived ancestry-specific and multi-ancestry PRS(CHD) based on pruning...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441485/ https://www.ncbi.nlm.nih.gov/pubmed/37609230 http://dx.doi.org/10.1101/2023.06.02.23290896 |