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A Multi-Ancestry Polygenic Risk Score for Coronary Heart Disease Based on an Ancestrally Diverse Genome-Wide Association Study and Population-Specific Optimization

BACKGROUND: Predictive performance of polygenic risk scores (PRS) varies across populations. To facilitate equitable clinical use, we developed PRS for coronary heart disease (PRS(CHD)) for 5 genetic ancestry groups. METHODS: We derived ancestry-specific and multi-ancestry PRS(CHD) based on pruning...

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Detalles Bibliográficos
Autores principales:	Smith, Johanna L., Tcheandjieu, Catherine, Dikilitas, Ozan, lyer, Kruthika, Miyazawa, Kazuo, Hilliard, Austin, Lynch, Julie, Rotter, Jerome I., Chen, Yii-Der Ida, Sheu, Wayne Huey-Herng, Chang, Kyong-Mi, Kanoni, Stavroula, Tsao, Phil, Ito, Kaoru, Kosel, Matthew, Clarke, Shoa L., Schaid, Daniel J., Assimes, Themistocles L., Kullo, Iftikhar J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441485/ https://www.ncbi.nlm.nih.gov/pubmed/37609230 http://dx.doi.org/10.1101/2023.06.02.23290896

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