Cargando…

ABCB1 and ABCG2 Regulation at the Blood-Brain Barrier: Potential New Targets to Improve Brain Drug Delivery

The drug efflux transporters ABCB1 and ABCG2 at the blood-brain barrier limit the delivery of drugs into the brain. Strategies to overcome ABCB1/ABCG2 have been largely unsuccessful, which poses a tremendous clinical problem to successfully treat central nervous system (CNS) diseases. Understanding...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schulz, Julia A., Hartz, Anika M.S., Bauer, Björn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Pharmacology and Experimental Therapeutics 2023
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441638/ https://www.ncbi.nlm.nih.gov/pubmed/36973040 http://dx.doi.org/10.1124/pharmrev.120.000025

Ejemplares similares

Pilot PET Study to Assess the Functional Interplay Between ABCB1 and ABCG2 at the Human Blood–Brain Barrier
por: Bauer, M, et al.
Publicado: (2016)

Identification of NanoLuciferase Substrates Transported by Human ABCB1 and ABCG2 and their Zebrafish Homologs at the Blood-Brain Barrier
por: Inglut, Collin T., et al.
Publicado: (2023)

Proteasome inhibition protects blood–brain barrier P-glycoprotein and lowers Aβ brain levels in an Alzheimer’s disease model
por: Vulin, Milica, et al.
Publicado: (2023)

442 Repurposing FDA-approved PI3K/Akt Inhibitors to Improve Anti-Cancer Drug Brain Uptake in Glioblastoma Resection Models
por: Rodgers, Louis, et al.
Publicado: (2022)

Assessment of brain delivery of a model ABCB1/ABCG2 substrate in patients with non-contrast-enhancing brain tumors with positron emission tomography
por: Wulkersdorfer, Beatrix, et al.
Publicado: (2019)

Protecting P-glycoprotein at the blood–brain barrier from degradation in an Alzheimer’s disease mouse model
por: Ding, Yujie, et al.
Publicado: (2021)

Improved Brain Penetration and Antitumor Efficacy of Temozolomide by Inhibition of ABCB1 and ABCG2()
por: de Gooijer, Mark C., et al.
Publicado: (2018)

Abcg2a is the functional homolog of human ABCG2 expressed at the zebrafish blood-brain barrier
por: Thomas, Joanna R., et al.
Publicado: (2023)

Smuggling Drugs into the Brain: An Overview of Ligands Targeting Transcytosis for Drug Delivery across the Blood–Brain Barrier
por: Georgieva, Julia V., et al.
Publicado: (2014)

ABCB1 and ABCG2 Together Limit the Distribution of ABCB1/ABCG2 Substrates to the Human Retina and the ABCG2 Single Nucleotide Polymorphism Q141K (c.421C> A) May Lead to Increased Drug Exposure
por: El Biali, Myriam, et al.
Publicado: (2021)

Modulation of the Blood–Brain Barrier for Drug Delivery to Brain
por: Han, Liang
Publicado: (2021)

Novel Intrinsic Mechanisms of Active Drug Extrusion at the Blood-Brain Barrier: Potential Targets for Enhancing Drug Delivery to the Brain?
por: Löscher, Wolfgang, et al.
Publicado: (2020)

Harnessing Ultrasound for Targeting Drug Delivery to the Brain and Breaching the Blood–Brain Tumour Barrier
por: Barzegar-Fallah, Anita, et al.
Publicado: (2022)

The Blood-Brain Barrier: Clinical Implications for Drug Delivery to the Brain
por: De Boer, A G, et al.
Publicado: (1994)

Advanced Blood–Brain Barrier Drug Delivery
por: Pardridge, William M.
Publicado: (2022)

Brain Distribution of Dual ABCB1/ABCG2 Substrates Is Unaltered in a Beta-Amyloidosis Mouse Model
por: Wanek, Thomas, et al.
Publicado: (2020)

Intraosseous administration into the skull: Potential blood–brain barrier bypassing route for brain drug delivery
por: Kang, Ji Hee, et al.
Publicado: (2022)

Evolution of blood–brain barrier in brain diseases and related systemic nanoscale brain-targeting drug delivery strategies
por: Han, Liang, et al.
Publicado: (2021)

Characterization and comparison of human glioblastoma models
por: Schulz, Julia A., et al.
Publicado: (2022)

Nanoscale drug delivery systems and the blood–brain barrier
por: Alyautdin, Renad, et al.
Publicado: (2014)

Peptide Shuttles for Blood–Brain Barrier Drug Delivery
por: Sánchez-Navarro, Macarena, et al.
Publicado: (2022)

The blood–brain barrier: structure, regulation, and drug delivery
por: Wu, Di, et al.
Publicado: (2023)

Epigenetic modulation of the drug resistance genes MGMT, ABCB1 and ABCG2 in glioblastoma multiforme
por: Oberstadt, Moritz C, et al.
Publicado: (2013)

Expression and function of Abcg4 in the mouse blood-brain barrier: role in restricting the brain entry of amyloid-β peptide
por: Dodacki, Agnès, et al.
Publicado: (2017)

Nanotherapeutics for Nose-to-Brain Drug Delivery: An Approach to Bypass the Blood Brain Barrier
por: Lee, David, et al.
Publicado: (2021)

Proteolysis-Targeting Chimera (PROTAC) Delivery into the Brain across the Blood-Brain Barrier
por: Tashima, Toshihiko
Publicado: (2023)

Rheumatoid Arthritis Disease Activity Is Determinant for ABCB1 and ABCG2 Drug-Efflux Transporters Function
por: Atisha-Fregoso, Yemil, et al.
Publicado: (2016)

Sitravatinib Sensitizes ABCB1- and ABCG2-Overexpressing Multidrug-Resistant Cancer Cells to Chemotherapeutic Drugs
por: Wu, Chung-Pu, et al.
Publicado: (2020)

Nanocarriers as Potential Drug Delivery Candidates for Overcoming the Blood–Brain Barrier: Challenges and Possibilities
por: Ahlawat, Jyoti, et al.
Publicado: (2020)

Drug Delivery Systems, CNS Protection, and the Blood Brain Barrier
por: Upadhyay, Ravi Kant
Publicado: (2014)

Evolving Drug Delivery Strategies to Overcome the Blood Brain Barrier
por: Hersh, David S., et al.
Publicado: (2016)

Treatment of Alzheimer’s Disease and Blood–Brain Barrier Drug Delivery
por: Pardridge, William M.
Publicado: (2020)

Blood–Brain Barrier Modulation to Improve Glioma Drug Delivery
por: Luo, Huilong, et al.
Publicado: (2020)

Pharmacoproteomics of Brain Barrier Transporters and Substrate Design for the Brain Targeted Drug Delivery
por: Huttunen, Kristiina M., et al.
Publicado: (2022)

Ultrasound-targeted nanoparticle delivery across the blood-brain barrier
por: Price, Richard
Publicado: (2015)

Permeabilization of the Blood-Brain Barrier via Mucosal Engrafting: Implications for Drug Delivery to the Brain
por: Bleier, Benjamin S., et al.
Publicado: (2013)

Established and Emerging Strategies for Drug Delivery Across the Blood-Brain Barrier in Brain Cancer
por: Parodi, Alessandro, et al.
Publicado: (2019)

Potential of Lipid-Based Nanocarriers against Two Major Barriers to Drug Delivery—Skin and Blood–Brain Barrier
por: Khan, Mohammad Sameer, et al.
Publicado: (2023)

Aryl hydrocarbon receptor-dependent upregulation of Cyp1b1 by TCDD and diesel exhaust particles in rat brain microvessels
por: Jacob, Aude, et al.
Publicado: (2011)

Drug-Resistant Epilepsy: Multiple Hypotheses, Few Answers
por: Tang, Fei, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_9b2cuinmaiqka65ki14q7ppv96