Mitochondrial impairment and synaptic dysfunction are associated with neurological defects in iPSCs-derived cortical neurons of MERRF patients

BACKGROUND: Myoclonic epilepsy with ragged-red fibers (MERRF) syndrome is a rare inherited mitochondrial disease mainly caused by the m.8344A > G mutation in mitochondrial tRNA(Lys) gene, and usually manifested as complex neurological disorders and muscle weakness. Currently, the pathogenic mecha...

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Detalles Bibliográficos
Autores principales: Wu, Yu-Ting, Tay, Hui-Yi, Yang, Jung-Tse, Liao, Hsiao-Hui, Ma, Yi-Shing, Wei, Yau-Huei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441704/
https://www.ncbi.nlm.nih.gov/pubmed/37605213
http://dx.doi.org/10.1186/s12929-023-00966-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441704/
https://www.ncbi.nlm.nih.gov/pubmed/37605213
http://dx.doi.org/10.1186/s12929-023-00966-8

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