Safety, Reactogenicity, Immunogenicity, and Dose Selection of 10-Valent Extraintestinal Pathogenic Escherichia coli Bioconjugate Vaccine (VAC52416) in Adults Aged 60–85 Years in a Randomized, Multicenter, Interventional, First-in-Human, Phase 1/2a Study

BACKGROUND: ExPEC10V is a bioconjugate vaccine containing O-antigen polysaccharides of 10 extraintestinal pathogenic Escherichia coli (ExPEC) serotypes. This phase 1/2a study (NCT03819049) assessed the safety, reactogenicity, and immunogenicity of ExPEC10V (VAC52416) to prevent invasive E coli disea...

Descripción completa

Detalles Bibliográficos
Autores principales: Fierro, Carlos A, Sarnecki, Michal, Doua, Joachim, Spiessens, Bart, Go, Oscar, Davies, Todd A, van den Dobbelsteen, Germie, Poolman, Jan, Abbanat, Darren, Haazen, Wouter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Major Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442062/
https://www.ncbi.nlm.nih.gov/pubmed/37608916
http://dx.doi.org/10.1093/ofid/ofad417

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442062/
https://www.ncbi.nlm.nih.gov/pubmed/37608916
http://dx.doi.org/10.1093/ofid/ofad417

Ejemplares similares