A3907, a systemic ASBT inhibitor, improves cholestasis in mice by multiorgan activity and shows translational relevance to humans

BACKGROUND AND AIMS: Cholestasis is characterized by intrahepatic accumulation of bile constituents, including bile acids (BAs), which promote liver damage. The apical sodium-dependent BA transporter (ASBT) plays an important role in BA reabsorption and signaling in ileum, bile ducts, and kidneys. O...

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Detalles Bibliográficos
Autores principales: Caballero-Camino, Francisco J., Rodrigues, Pedro M., Wångsell, Fredrik, Agirre-Lizaso, Aloña, Olaizola, Paula, Izquierdo-Sanchez, Laura, Perugorria, Maria J., Bujanda, Luis, Angelin, Bo, Straniero, Sara, Wallebäck, Anna, Starke, Ingemar, Gillberg, Per-Göran, Strängberg, Ellen, Bonn, Britta, Mattsson, Jan P., Madsen, Martin R., Hansen, Henrik H., Lindström, Erik, Åkerblad, Peter, Banales, Jesus M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Original Articles: Immune-Mediated Diseases, DILI, and Biliary Tract Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442107/
https://www.ncbi.nlm.nih.gov/pubmed/36999529
http://dx.doi.org/10.1097/HEP.0000000000000376

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442107/
https://www.ncbi.nlm.nih.gov/pubmed/36999529
http://dx.doi.org/10.1097/HEP.0000000000000376

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