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Structural basis of sequence-specific cytosine deamination by double-stranded DNA deaminase toxin DddA
The interbacterial deaminase toxin DddA catalyzes cytosine-to-uracil conversion in double-stranded (ds) DNA and enables CRISPR-free mitochondrial base editing, but the molecular mechanisms underlying its unique substrate selectivity have remained elusive. Here, we report crystal structures of DddA b...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group US
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442228/ https://www.ncbi.nlm.nih.gov/pubmed/37460895 http://dx.doi.org/10.1038/s41594-023-01034-3 |