Exploration of novel αβ-protein folds through de novo design

A fundamental question in protein evolution is whether nature has exhaustively sampled nearly all possible protein folds throughout evolution, or whether a large fraction of the possible folds remains unexplored. To address this question, we defined a set of rules for β-sheet topology to predict nov...

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Detalles Bibliográficos
Autores principales: Minami, Shintaro, Kobayashi, Naohiro, Sugiki, Toshihiko, Nagashima, Toshio, Fujiwara, Toshimichi, Tatsumi-Koga, Rie, Chikenji, George, Koga, Nobuyasu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442233/
https://www.ncbi.nlm.nih.gov/pubmed/37400653
http://dx.doi.org/10.1038/s41594-023-01029-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442233/
https://www.ncbi.nlm.nih.gov/pubmed/37400653
http://dx.doi.org/10.1038/s41594-023-01029-0

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