Cargando…

Pancreatic acinar cell fate relies on system x(C)(-) to prevent ferroptosis during stress

Acinar cell dedifferentiation is one of the most notable features of acute and chronic pancreatitis. It can also be the initial step that facilitates pancreatic cancer development. In the present study, we further decipher the precise mechanisms and regulation using primary human cells and murine ex...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pan, Zhaolong, Van den Bossche, Jan-Lars, Rodriguez-Aznar, Eva, Janssen, Pauline, Lara, Olaya, Ates, Gamze, Massie, Ann, De Paep, Diedert Luc, Houbracken, Isabelle, Mambretti, Marco, Rooman, Ilse
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442358/ https://www.ncbi.nlm.nih.gov/pubmed/37604805 http://dx.doi.org/10.1038/s41419-023-06063-w

Ejemplares similares

MECOM permits pancreatic acinar cell dedifferentiation avoiding cell death under stress conditions
por: Backx, Elyne, et al.
Publicado: (2021)

Adult human pancreatic acinar cells dedifferentiate into an embryonic progenitor-like state in 3D suspension culture
por: Baldan, Jonathan, et al.
Publicado: (2019)

Acinar cells in the neonatal pancreas grow by self-duplication and not by neogenesis from duct cells
por: Houbracken, Isabelle, et al.
Publicado: (2017)

On the Origin of Pancreatic Cancer: Molecular Tumor Subtypes in Perspective of Exocrine Cell Plasticity
por: Backx, Elyne, et al.
Publicado: (2021)

Insulitis in the pancreas of non-diabetic organ donors under age 25 years with multiple circulating autoantibodies against islet cell antigens
por: Smeets, Silke, et al.
Publicado: (2021)

Acinar phenotype is preserved in human exocrine pancreas cells cultured at low temperature: implications for lineage-tracing of β-cell neogenesis
por: Mfopou, Josué K., et al.
Publicado: (2016)

Cystine–glutamate antiporter deletion accelerates motor recovery and improves histological outcomes following spinal cord injury in mice
por: Sprimont, Lindsay, et al.
Publicado: (2021)

Ferroptosis: Cancer Stem Cells Rely on Iron until “to Die for” It
por: Cosialls, Emma, et al.
Publicado: (2021)

Secondary iron overload induces chronic pancreatitis and ferroptosis of acinar cells in mice
por: Tian, Chenying, et al.
Publicado: (2022)

AMPKα1 Deficiency in Astrocytes from a Rat Model of ALS Is Associated with an Altered Metabolic Resilience
por: Belo do Nascimento, Inês, et al.
Publicado: (2023)

Mitochondrial Targeting of Antioxidants Alters Pancreatic Acinar Cell Bioenergetics and Determines Cell Fate
por: Armstrong, Jane A., et al.
Publicado: (2019)

Nicotinamide combined with gemcitabine is an immunomodulatory therapy that restrains pancreatic cancer in mice
por: Selvanesan, Benson Chellakkan, et al.
Publicado: (2020)

Editorial: The role of mitochondria and ferroptosis in cell fate
por: Lin, Yingwen, et al.
Publicado: (2022)

Lower beta cell yield from donor pancreases after controlled circulatory death prevented by shortening acirculatory warm ischemia time and by using IGL-1 cold preservation solution
por: De Paep, Diedert L., et al.
Publicado: (2021)

Oxytosis/Ferroptosis—(Re-) Emerging Roles for Oxidative Stress-Dependent Non-apoptotic Cell Death in Diseases of the Central Nervous System
por: Lewerenz, Jan, et al.
Publicado: (2018)

Uptake and fate of luminally administered horseradish peroxidase in resting and isoproterenol-stimulated rat parotid acinar cells
Publicado: (1978)

AMPK Modulates the Metabolic Adaptation of C6 Glioma Cells in Glucose-Deprived Conditions without Affecting Glutamate Transport
por: Belo do Nascimento, Inês, et al.
Publicado: (2022)

Validation of a System x(c)(–) Functional Assay in Cultured Astrocytes and Nervous Tissue Samples
por: Beckers, Pauline, et al.
Publicado: (2022)

Transcriptional Profile of Human Pancreatic Acinar Ductal Metaplasia
por: Jiang, Jinmai, et al.
Publicado: (2023)

The Activation of Endothelial Cells Relies on a Ferroptosis-Like Mechanism: Novel Perspectives in Management of Angiogenesis and Cancer Therapy
por: Lopes-Coelho, Filipa, et al.
Publicado: (2021)

Utility of Islet Cell Preparations From Donor Pancreases After Euthanasia
por: De Paep, Diedert L., et al.
Publicado: (2022)

Pharmacological inhibition and reversal of pancreatic acinar ductal metaplasia
por: da Silva, Lais, et al.
Publicado: (2022)

Discovery and 3D imaging of a novel ΔNp63-expressing basal cell type in human pancreatic ducts with implications in disease
por: Martens, Sandrina, et al.
Publicado: (2022)

Chronic Sulfasalazine Treatment in Mice Induces System x(c) (−) - Independent Adverse Effects
por: Verbruggen, Lise, et al.
Publicado: (2021)

Lifespan extension with preservation of hippocampal function in aged system x(c)(−)-deficient male mice
por: Verbruggen, Lise, et al.
Publicado: (2022)

Acinar Cell Cystadenoma (Acinar Cystic Transformation) of the Pancreas: the Radiologic-Pathologic Features
por: Gumus, Mehmet, et al.
Publicado: (2011)

Sirtainties in pancreatic cancer?
por: Rooman, Ilse
Publicado: (2014)

Maintenance of Acinar Cell Organization is Critical to Preventing Kras-Induced Acinar-Ductal Metaplasia
por: Shi, Guanglu, et al.
Publicado: (2012)

TGF-β1 promotes acinar to ductal metaplasia of human pancreatic acinar cells
por: Liu, Jun, et al.
Publicado: (2016)

Golgi relies on centrin
por: LeBrasseur, Nicole
Publicado: (2005)

Acinar Cell Cystadenocarcinoma of the Pancreas
por: Aoto, Keita, et al.
Publicado: (2017)

Pancreatic Acinar Cell Carcinoma
por: Béchade, Dominique, et al.
Publicado: (2016)

PD2/Paf1 depletion in pancreatic acinar cells promotes acinar-to-ductal metaplasia
por: Dey, Parama, et al.
Publicado: (2014)

Gene delivery to pancreatic exocrine cells in vivo and in vitro
por: Houbracken, Isabelle, et al.
Publicado: (2012)

Identification of AP-1 as a Critical Regulator of Glutathione Peroxidase 4 (GPX4) Transcriptional Suppression and Acinar Cell Ferroptosis in Acute Pancreatitis
por: Ma, Xiaojie, et al.
Publicado: (2022)

Luteolin inhibits pancreatitis-induced acinar-ductal metaplasia, proliferation and epithelial-mesenchymal transition of acinar cells
por: Huang, Xince, et al.
Publicado: (2018)

Regulated Exocytosis in the Pancreatic Acinar Cell
por: Jamieson, J.D., et al.
Publicado: (1997)

Discussion: Pancreatic Acinar Cell Pathophysiology
por: Gorelick, Fred S.
Publicado: (1992)

SULFATE METABOLISM IN PANCREATIC ACINAR CELLS
por: Berg, Norton B., et al.
Publicado: (1971)

Effects of Benzodiazepines on Acinar and Myoepithelial Cells
por: Mattioli, Tatiana M. F., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_prtnp6egb2biccbvs9ju4blv8i