A mechanistic reinterpretation of fast inactivation in voltage-gated Na(+) channels

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The hinged-lid model was long accepted as the canonical model for fast inactivation in Nav channels. It predicts that the hydrophobic IFM motif acts intracellularly as the gating particle that binds and occludes the pore during fast inactivation. However, the observation in recent high-resolution st...

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Detalles Bibliográficos
Autores principales: Liu, Yichen, Bassetto, Carlos A. Z., Pinto, Bernardo I., Bezanilla, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442390/
https://www.ncbi.nlm.nih.gov/pubmed/37604801
http://dx.doi.org/10.1038/s41467-023-40514-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442390/
https://www.ncbi.nlm.nih.gov/pubmed/37604801
http://dx.doi.org/10.1038/s41467-023-40514-4

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