Crystal structure and functional implications of cyclic di-pyrimidine-synthesizing cGAS/DncV-like nucleotidyltransferases

Purine-containing nucleotide second messengers regulate diverse cellular activities. Cyclic di-pyrimidines mediate anti-phage functions in bacteria; however, the synthesis mechanism remains elusive. Here, we determine the high-resolution structures of cyclic di-pyrimidine-synthesizing cGAS/DncV-like...

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Detalles Bibliográficos
Autores principales: Yang, Chia-Shin, Ko, Tzu-Ping, Chen, Chao-Jung, Hou, Mei-Hui, Wang, Yu-Chuan, Chen, Yeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442399/
https://www.ncbi.nlm.nih.gov/pubmed/37604815
http://dx.doi.org/10.1038/s41467-023-40787-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442399/
https://www.ncbi.nlm.nih.gov/pubmed/37604815
http://dx.doi.org/10.1038/s41467-023-40787-9

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