Multiple LDLR class A repeats on very‐low‐density lipoprotein receptor promote the cross‐species transmission of Semliki Forest virus

Multiple LDLR class A (LA) repeats around LA3 promote synergistic binding to Semliki Forest virus (SFV) E1‐DIII near the 2‐fold and 5‐fold symmetry axes. Meanwhile, the multiple consecutive LAs concatemer shows approximately 1000 times higher binding affinity than that of LA3s, which can help to eff...

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Detalles Bibliográficos
Autores principales: Hu, Ruolan, Li, Maochen, Fan, Huahao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Highlights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442473/
https://www.ncbi.nlm.nih.gov/pubmed/37614966
http://dx.doi.org/10.1002/mco2.351
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author Hu, Ruolan
Li, Maochen
Fan, Huahao
author_facet Hu, Ruolan
Li, Maochen
Fan, Huahao
author_sort Hu, Ruolan
collection PubMed
description Multiple LDLR class A (LA) repeats around LA3 promote synergistic binding to Semliki Forest virus (SFV) E1‐DIII near the 2‐fold and 5‐fold symmetry axes. Meanwhile, the multiple consecutive LAs concatemer shows approximately 1000 times higher binding affinity than that of LA3s, which can help to effectively and synergistically bind with E1‐DIII of viral envelope protein. [Image: see text]
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spelling pubmed-104424732023-08-23 Multiple LDLR class A repeats on very‐low‐density lipoprotein receptor promote the cross‐species transmission of Semliki Forest virus Hu, Ruolan Li, Maochen Fan, Huahao MedComm (2020) Highlights Multiple LDLR class A (LA) repeats around LA3 promote synergistic binding to Semliki Forest virus (SFV) E1‐DIII near the 2‐fold and 5‐fold symmetry axes. Meanwhile, the multiple consecutive LAs concatemer shows approximately 1000 times higher binding affinity than that of LA3s, which can help to effectively and synergistically bind with E1‐DIII of viral envelope protein. [Image: see text] John Wiley and Sons Inc. 2023-08-21 /pmc/articles/PMC10442473/ /pubmed/37614966 http://dx.doi.org/10.1002/mco2.351 Text en © 2023 The Authors. MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Highlights
Hu, Ruolan
Li, Maochen
Fan, Huahao
Multiple LDLR class A repeats on very‐low‐density lipoprotein receptor promote the cross‐species transmission of Semliki Forest virus
title Multiple LDLR class A repeats on very‐low‐density lipoprotein receptor promote the cross‐species transmission of Semliki Forest virus
title_full Multiple LDLR class A repeats on very‐low‐density lipoprotein receptor promote the cross‐species transmission of Semliki Forest virus
title_fullStr Multiple LDLR class A repeats on very‐low‐density lipoprotein receptor promote the cross‐species transmission of Semliki Forest virus
title_full_unstemmed Multiple LDLR class A repeats on very‐low‐density lipoprotein receptor promote the cross‐species transmission of Semliki Forest virus
title_short Multiple LDLR class A repeats on very‐low‐density lipoprotein receptor promote the cross‐species transmission of Semliki Forest virus
title_sort multiple ldlr class a repeats on very‐low‐density lipoprotein receptor promote the cross‐species transmission of semliki forest virus
topic Highlights
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442473/
https://www.ncbi.nlm.nih.gov/pubmed/37614966
http://dx.doi.org/10.1002/mco2.351
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AT fanhuahao multipleldlrclassarepeatsonverylowdensitylipoproteinreceptorpromotethecrossspeciestransmissionofsemlikiforestvirus

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