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Small GTP‐binding protein Rap1 mediates EGF and HB‐EGF signaling and modulates EGF receptor expression in HTR‐8/SVneo extravillous trophoblast cells

PURPOSE: Extravillous trophoblasts (EVTs) invade the endometrium to establish a fetomaternal interaction during pregnancy. Epidermal growth factor (EGF) and heparin‐binding EGF‐like growth factor (HB‐EGF) stimulate EVT invasion by binding to the EGF receptor (EGFR). We examined the role of the small...

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Detalles Bibliográficos
Autores principales: Yoshie, Mikihiro, Ohishi, Kensuke, Ishikawa, Gen, Tsuru, Atsuya, Kusama, Kazuya, Azumi, Mana, Tamura, Kazuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442520/
https://www.ncbi.nlm.nih.gov/pubmed/37614815
http://dx.doi.org/10.1002/rmb2.12537