O-GlcNAc Modification Alters the Chaperone Activity of HSP27 Charcot-Marie-Tooth Type 2 (CMT2) Variants in a Mutation-Selective Fashion

[Image: see text] Increased O-GlcNAc is a common feature of cellular stress, and the upregulation of this dynamic modification is associated with improved survival under these conditions. Likewise, the heat shock proteins are also increased under stress and prevent protein misfolding and aggregation...

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Detalles Bibliográficos
Autores principales: Moon, Stuart P., Wang, Binyou, Ahn, Benjamin S., Ryu, Andrew H., Hard, Eldon R., Javed, Afraah, Pratt, Matthew R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442854/
https://www.ncbi.nlm.nih.gov/pubmed/37540114
http://dx.doi.org/10.1021/acschembio.3c00292

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442854/
https://www.ncbi.nlm.nih.gov/pubmed/37540114
http://dx.doi.org/10.1021/acschembio.3c00292

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