Targeted Protein Degradation through Recruitment of the CUL4A Complex Adaptor Protein DDB1

Targeted protein degradation has arisen as a powerful therapeutic modality for eliminating proteins. Thus far, most heterobifunctional Proteolysis Targeting Chimeras (PROTACs) have utilized recruiters against substrate receptors of Cullin RING E3 ubiquitin ligases, such as cereblon and VHL. However,...

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Detalles Bibliográficos
Autores principales: Meyers, Margot, Cismoski, Sabine, Panidapu, Anoohya, Chie-Leon, Barbara, Nomura, Daniel K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443223/
https://www.ncbi.nlm.nih.gov/pubmed/37614621
http://dx.doi.org/10.1101/2023.08.11.553046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443223/
https://www.ncbi.nlm.nih.gov/pubmed/37614621
http://dx.doi.org/10.1101/2023.08.11.553046

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