Cargando…

Targeted Protein Degradation through Recruitment of the CUL4A Complex Adaptor Protein DDB1

Targeted protein degradation has arisen as a powerful therapeutic modality for eliminating proteins. Thus far, most heterobifunctional Proteolysis Targeting Chimeras (PROTACs) have utilized recruiters against substrate receptors of Cullin RING E3 ubiquitin ligases, such as cereblon and VHL. However,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Meyers, Margot, Cismoski, Sabine, Panidapu, Anoohya, Chie-Leon, Barbara, Nomura, Daniel K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443223/ https://www.ncbi.nlm.nih.gov/pubmed/37614621 http://dx.doi.org/10.1101/2023.08.11.553046

Ejemplares similares

Targeted Ubiquitination and Degradation of G-Protein-Coupled Receptor Kinase 5 by the DDB1-CUL4 Ubiquitin Ligase Complex
por: Wu, Ziyan, et al.
Publicado: (2012)

NRIP/DCAF6 stabilizes the androgen receptor protein by displacing DDB2 from the CUL4A-DDB1 E3 ligase complex in prostate cancer
por: Chen, Hsin-Hsiung, et al.
Publicado: (2017)

Cul3 substrate adaptor SPOP targets Nup153 for degradation
por: Ong, Joseph Y., et al.
Publicado: (2023)

Regulation and Role of Arabidopsis CUL4-DDB1A-DDB2 in Maintaining Genome Integrity upon UV Stress
por: Molinier, Jean, et al.
Publicado: (2008)

Stealing the spotlight: CUL4-DDB1 ubiquitin ligase docks WD40-repeat proteins to destroy
por: Higa, Leigh Ann, et al.
Publicado: (2007)

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates
por: Raisch, Jennifer, et al.
Publicado: (2023)

The CUL4-DDB1 ubiquitin ligase complex controls adult and embryonic stem cell differentiation and homeostasis
por: Gao, Jie, et al.
Publicado: (2015)

LZTR1: A promising adaptor of the CUL3 family
por: Zhang, Hui, et al.
Publicado: (2021)

CUL4B-DDB1-COP1-mediated UTX downregulation promotes colorectal cancer progression
por: Luo, Dakui, et al.
Publicado: (2023)

The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stability
por: Zhang, Ling, et al.
Publicado: (2012)

DCAF26, an Adaptor Protein of Cul4-Based E3, Is Essential for DNA Methylation in Neurospora crassa
por: Xu, Hui, et al.
Publicado: (2010)

CUL4-DDB1-CDT2 E3 Ligase Regulates the Molecular Clock Activity by Promoting Ubiquitination-Dependent Degradation of the Mammalian CRY1
por: Tong, Xin, et al.
Publicado: (2015)

The CRBN, CUL4A and DDB1 Expression Predicts the Response to Immunomodulatory Drugs and Survival of Multiple Myeloma Patients
por: Barankiewicz, Joanna, et al.
Publicado: (2021)

Stability of HIB-Cul3 E3 ligase adaptor HIB Is Regulated by Self-degradation and Availability of Its Substrates
por: Zhou, Zizhang, et al.
Publicado: (2015)

Recruitment of the Adaptor Protein Grb2 to EGFR Tetramers
por: Kozer, Noga, et al.
Publicado: (2014)

The HIV-2 Vpx protein usurps the Cul4A-DDB1-DCAF1 ubiquitin ligase to overcome a post-entry block in macrophage infection
por: Ayinde, Diana, et al.
Publicado: (2009)

The Fifth Adaptor Protein Complex
por: Hirst, Jennifer, et al.
Publicado: (2011)

Exploiting the Cullin E3 Ligase Adaptor Protein SKP1 for Targeted Protein Degradation
por: Hong, Seong Ho, et al.
Publicado: (2023)

FBXO44-Mediated Degradation of RGS2 Protein Uniquely Depends on a Cullin 4B/DDB1 Complex
por: Sjögren, Benita, et al.
Publicado: (2015)

Deletion of DDB1- and CUL4- associated factor-17 (Dcaf17) gene causes spermatogenesis defects and male infertility in mice
por: Ali, Asmaa, et al.
Publicado: (2018)

Integrative analysis of multi-omics data reveals distinct impacts of DDB1-CUL4 associated factors in human lung adenocarcinomas
por: Yan, Hong, et al.
Publicado: (2017)

Cul4-Ddb1 ubiquitin ligases facilitate DNA replication-coupled sister chromatid cohesion through regulation of cohesin acetyltransferase Esco2
por: Sun, Haitao, et al.
Publicado: (2019)

Correction: The Fifth Adaptor Protein Complex
por: Hirst, Jennifer, et al.
Publicado: (2012)

Adaptor protein complexes and intracellular transport
por: Park, Sang Yoon, et al.
Publicado: (2014)

PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1
por: Pines, Alex, et al.
Publicado: (2012)

The replication initiation determinant protein (RepID) modulates replication by recruiting CUL4 to chromatin
por: Jang, Sang-Min, et al.
Publicado: (2018)

Targeted Protein Degradation through E2 Recruitment
por: Forte, Nafsika, et al.
Publicado: (2023)

HIV-1 Vpr-Mediated G2 Arrest Involves the DDB1-CUL4A(VPRBP) E3 Ubiquitin Ligase
por: Belzile, Jean-Philippe, et al.
Publicado: (2007)

Publisher Correction: Deletion of DDB1- and CUL4- associated factor-17 (Dcaf17) gene causes spermatogenesis defects and male infertility in mice
por: Ali, Asmaa, et al.
Publicado: (2018)

CUL4-DDB1-CRBN E3 Ubiquitin Ligase Regulates Proteostasis of ClC-2 Chloride Channels: Implication for Aldosteronism and Leukodystrophy
por: Fu, Ssu-Ju, et al.
Publicado: (2020)

Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex
por: Minor, Marissa M., et al.
Publicado: (2020)

A novel adaptor-related protein complex
Publicado: (1996)

DDB2 regulates DNA replication through PCNA-independent degradation of CDT2
por: Wu, Xiaojun, et al.
Publicado: (2021)

Monitoring Repair of UV-Induced 6-4-Photoproducts with a Purified DDB2 Protein Complex
por: Dreze, Matija, et al.
Publicado: (2014)

Cul3 and the BTB Adaptor Insomniac Are Key Regulators of Sleep Homeostasis and a Dopamine Arousal Pathway in Drosophila
por: Pfeiffenberger, Cory, et al.
Publicado: (2012)

Basolateral Sorting of the Sodium/Iodide Symporter Is Mediated by Adaptor Protein 1 Clathrin Adaptor Complexes
por: Koumarianou, Petrina, et al.
Publicado: (2022)

CUL3/SPOP complex prevents immune escape and enhances chemotherapy sensitivity of ovarian cancer cells through degradation of PD-L1 protein
por: Dong, Min, et al.
Publicado: (2022)

Characterization of the Adaptor-related Protein Complex, AP-3
por: Simpson, Fiona, et al.
Publicado: (1997)

Targeted CUL4A inhibition synergizes with cisplatin to yield long-term survival in models of head and neck squamous cell carcinoma through a DDB2-mediated mechanism
por: Jones, Trace M., et al.
Publicado: (2022)

Novel Cul3 binding proteins function to remodel E3 ligase complexes
por: Wimuttisuk, Wananit, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_57coj5l7b8ghfhd261etrlrsmc