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YAP Inactivation by Soft Mechanotransduction Relieves MAFG for Tumor Cell Dedifferentiation
Solid tumor cells live in a highly dynamic mechanical microenvironment. How the extracellular-matrix-generated mechanotransduction regulates tumor cell development and differentiation remains an enigma. Here, we show that a low mechanical force generated from the soft matrix induces dedifferentiatio...
Autores principales: | Lv, Jiadi, Liu, Xiaohan, Zhou, Yabo, Cheng, Feiran, Chen, Haoran, Li, Shunshun, Wang, Dianheng, Zhou, Li, Wang, Zhenfeng, Zhou, Nannan, Chen, Jie, Huang, Bo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AAAS
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443527/ https://www.ncbi.nlm.nih.gov/pubmed/37614365 http://dx.doi.org/10.34133/research.0215 |
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