CRISPR interference to evaluate modifiers of C9ORF72-mediated toxicity in FTD

Treatments for neurodegenerative disease, including Frontotemporal dementia (FTD) and Amyotrophic lateral sclerosis (ALS), remain rather limited, underscoring the need for greater mechanistic insight and disease-relevant models. Our ability to develop novel disease models of genetic risk factors, di...

Descripción completa

Detalles Bibliográficos
Autores principales: Pickles, Sarah, Zanetti Alepuz, Desiree, Koike, Yuka, Yue, Mei, Tong, Jimei, Liu, Pinghu, Zhou, Yugui, Jansen-West, Karen, Daughrity, Lillian M., Song, Yuping, DeTure, Michael, Oskarsson, Björn, Graff-Radford, Neill R., Boeve, Bradley F., Petersen, Ronald C., Josephs, Keith A., Dickson, Dennis W., Ward, Michael E., Dong, Lijin, Prudencio, Mercedes, Cook, Casey N., Petrucelli, Leonard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443592/
https://www.ncbi.nlm.nih.gov/pubmed/37614226
http://dx.doi.org/10.3389/fcell.2023.1251551

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443592/
https://www.ncbi.nlm.nih.gov/pubmed/37614226
http://dx.doi.org/10.3389/fcell.2023.1251551

Ejemplares similares