Generating endogenous Myh11-driven Cre mice for sex-independent gene deletion in smooth muscle cells

Specific and efficient smooth muscle cell–targeted (SMC-targeted) gene deletion is typically achieved by pairing SMMHC-CreER(T2)-Tg mice with mice carrying the loxP-flanked gene. However, the transgene, CreER(T2), is not controlled by the endogenous Myh11 gene promoter, and the codon-modified iCreER...

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Detalles Bibliográficos
Autores principales: Zhao, Yang, Zhao, Guizhen, Chang, Ziyi, Zhu, Tianqing, Zhao, Ying, Lu, Haocheng, Xue, Chao, Saunders, Thomas L., Guo, Yanhong, Chang, Lin, Chen, Y. Eugene, Zhang, Jifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Technical Advance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443793/
https://www.ncbi.nlm.nih.gov/pubmed/37289544
http://dx.doi.org/10.1172/jci.insight.171661

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443793/
https://www.ncbi.nlm.nih.gov/pubmed/37289544
http://dx.doi.org/10.1172/jci.insight.171661

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