Deacetylation via SIRT2 prevents keratin-mutation-associated injury and keratin aggregation

Keratin (K) and other intermediate filament (IF) protein mutations at conserved arginines disrupt keratin filaments into aggregates and cause human epidermolysis bullosa simplex (EBS; K14-R125C) or predispose to mouse liver injury (K18-R90C). The challenge for more than 70 IF-associated diseases is...

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Detalles Bibliográficos
Autores principales: Sun, Jingyuan, Li, Pei, Gui, Honglian, Rittié, Laure, Lombard, David B., Rietscher, Katrin, Magin, Thomas M., Xie, Qing, Liu, Li, Omary, M. Bishr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443796/
https://www.ncbi.nlm.nih.gov/pubmed/37485877
http://dx.doi.org/10.1172/jci.insight.166314

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443796/
https://www.ncbi.nlm.nih.gov/pubmed/37485877
http://dx.doi.org/10.1172/jci.insight.166314

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