LIN28B promotes cell invasion and colorectal cancer metastasis via CLDN1 and NOTCH3

The RNA-binding protein LIN28B is overexpressed in over 30% of patients with colorectal cancer (CRC) and is associated with poor prognosis. In the present study, we unraveled a potentially novel mechanism by which LIN28B regulates colonic epithelial cell-cell junctions and CRC metastasis. Using huma...

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Detalles Bibliográficos
Autores principales: Sugiura, Kensuke, Masuike, Yasunori, Suzuki, Kensuke, Shin, Alice E., Sakai, Nozomu, Matsubara, Hisahiro, Otsuka, Masayuki, Sims, Peter A., Lengner, Christopher J., Rustgi, Anil K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443801/
https://www.ncbi.nlm.nih.gov/pubmed/37318881
http://dx.doi.org/10.1172/jci.insight.167310

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443801/
https://www.ncbi.nlm.nih.gov/pubmed/37318881
http://dx.doi.org/10.1172/jci.insight.167310

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