Calcineurin regulates aldosterone production via dephosphorylation of NFATC4

The mineralocorticoid aldosterone, secreted by the adrenal zona glomerulosa (ZG), is critical for life, maintaining ion homeostasis and blood pressure. Therapeutic inhibition of protein phosphatase 3 (calcineurin, Cn) results in inappropriately low plasma aldosterone levels despite concomitant hyper...

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Detalles Bibliográficos
Autores principales: Berber, Mesut, Leng, Sining, Wengi, Agnieszka, Winter, Denise V., Odermatt, Alex, Beuschlein, Felix, Loffing, Johannes, Breault, David T., Penton, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443813/
https://www.ncbi.nlm.nih.gov/pubmed/37310791
http://dx.doi.org/10.1172/jci.insight.157027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443813/
https://www.ncbi.nlm.nih.gov/pubmed/37310791
http://dx.doi.org/10.1172/jci.insight.157027

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