Design, optimization, production and activity testing of recombinant immunotoxins expressed in plants and plant cells for the treatment of monocytic leukemia

Antibody–drug conjugates (ADCs) can improve therapeutic indices compared to plain monoclonal antibodies (mAbs). However, ADC synthesis is complex because the components are produced separately in CHO cells (mAb) and often by chemical synthesis (drug). They are individually purified, coupled, and the...

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Detalles Bibliográficos
Autores principales: Knödler, Matthias, Frank, Katharina, Kerpen, Lucy, Buyel, Johannes Felix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10444015/
https://www.ncbi.nlm.nih.gov/pubmed/37598369
http://dx.doi.org/10.1080/21655979.2023.2244235

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10444015/
https://www.ncbi.nlm.nih.gov/pubmed/37598369
http://dx.doi.org/10.1080/21655979.2023.2244235

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