Design and synthesis of new spirooxindole candidates and their selenium nanoparticles as potential dual Topo I/II inhibitors, DNA intercalators, and apoptotic inducers

A new wave of dual Topo I/II inhibitors was designed and synthesised via the hybridisation of spirooxindoles and pyrimidines. In situ selenium nanoparticles (SeNPs) for some derivatives were synthesised. The targets and the SeNP derivatives were examined for their cytotoxicity towards five cancer ce...

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Detalles Bibliográficos
Autores principales: El-Kalyoubi, Samar, Khalifa, Mohamed M., Abo-Elfadl, Mahmoud T., El-Sayed, Ahmed A., Elkamhawy, Ahmed, Lee, Kyeong, Al-Karmalawy, Ahmed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10444021/
https://www.ncbi.nlm.nih.gov/pubmed/37592917
http://dx.doi.org/10.1080/14756366.2023.2242714

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10444021/
https://www.ncbi.nlm.nih.gov/pubmed/37592917
http://dx.doi.org/10.1080/14756366.2023.2242714

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