A systematic safety pipeline for selection of T-cell receptors to enter clinical use

Cancer immunotherapy using T cell receptor-engineered T cells (TCR-Ts) represents a promising treatment option. However, technologies for pre-clinical safety assessment are incomplete or inaccessible to most laboratories. Here, TCR-T off-target reactivity was assessed in five steps: (1) Mapping targ...

Descripción completa

Detalles Bibliográficos
Autores principales: Foldvari, Zsofia, Knetter, Cathrine, Yang, Weiwen, Gjerdingen, Thea Johanne, Bollineni, Ravi Chand, Tran, Trung The, Lund-Johansen, Fridtjof, Kolstad, Arne, Drousch, Kimberley, Klopfleisch, Robert, Leisegang, Matthias, Olweus, Johanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10444760/
https://www.ncbi.nlm.nih.gov/pubmed/37607971
http://dx.doi.org/10.1038/s41541-023-00713-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10444760/
https://www.ncbi.nlm.nih.gov/pubmed/37607971
http://dx.doi.org/10.1038/s41541-023-00713-y

Ejemplares similares