Impaired Plakophilin-2 in obesity breaks cell cycle dynamics to breed adipocyte senescence

Plakophilin-2 (PKP2) is a key component of desmosomes, which, when defective, is known to promote the fibro-fatty infiltration of heart muscle. Less attention has been given to its role in adipose tissue. We report here that levels of PKP2 steadily increase during fat cell differentiation, and are c...

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Detalles Bibliográficos
Autores principales: Lluch, Aina, Latorre, Jessica, Serena-Maione, Angela, Espadas, Isabel, Caballano-Infantes, Estefanía, Moreno-Navarrete, José M., Oliveras-Cañellas, Núria, Ricart, Wifredo, Malagón, María M., Martin-Montalvo, Alejandro, Birchmeier, Walter, Szymanski, Witold, Graumann, Johannes, Gómez-Serrano, María, Sommariva, Elena, Fernández-Real, José M., Ortega, Francisco J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10444784/
https://www.ncbi.nlm.nih.gov/pubmed/37607954
http://dx.doi.org/10.1038/s41467-023-40596-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10444784/
https://www.ncbi.nlm.nih.gov/pubmed/37607954
http://dx.doi.org/10.1038/s41467-023-40596-0

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