Structural insights into opposing actions of neurosteroids on GABA(A) receptors

γ-Aminobutyric acid type A (GABA(A)) receptors mediate fast inhibitory signaling in the brain and are targets of numerous drugs and endogenous neurosteroids. A subset of neurosteroids are GABA(A) receptor positive allosteric modulators; one of these, allopregnanolone, is the only drug approved speci...

Descripción completa

Detalles Bibliográficos
Autores principales: Legesse, Dagimhiwat H., Fan, Chen, Teng, Jinfeng, Zhuang, Yuxuan, Howard, Rebecca J., Noviello, Colleen M., Lindahl, Erik, Hibbs, Ryan E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10444788/
https://www.ncbi.nlm.nih.gov/pubmed/37607940
http://dx.doi.org/10.1038/s41467-023-40800-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10444788/
https://www.ncbi.nlm.nih.gov/pubmed/37607940
http://dx.doi.org/10.1038/s41467-023-40800-1

Ejemplares similares