Induction of open-form bile canaliculus formation by hepatocytes for evaluation of biliary drug excretion

Biliary excretion is a major drug elimination pathway that affects their efficacy and safety. The currently available in vitro sandwich-cultured hepatocyte method is cumbersome because drugs accumulate in the closed bile canalicular lumen formed between hepatocytes and their amounts cannot be mealsu...

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Detalles Bibliográficos
Autores principales: Arakawa, Hiroshi, Nakazono, Yuya, Matsuoka, Natsumi, Hayashi, Momoka, Shirasaka, Yoshiyuki, Hirao, Atsushi, Tamai, Ikumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10444810/
https://www.ncbi.nlm.nih.gov/pubmed/37608051
http://dx.doi.org/10.1038/s42003-023-05216-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10444810/
https://www.ncbi.nlm.nih.gov/pubmed/37608051
http://dx.doi.org/10.1038/s42003-023-05216-z

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