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Induction of open-form bile canaliculus formation by hepatocytes for evaluation of biliary drug excretion
Biliary excretion is a major drug elimination pathway that affects their efficacy and safety. The currently available in vitro sandwich-cultured hepatocyte method is cumbersome because drugs accumulate in the closed bile canalicular lumen formed between hepatocytes and their amounts cannot be mealsu...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10444810/ https://www.ncbi.nlm.nih.gov/pubmed/37608051 http://dx.doi.org/10.1038/s42003-023-05216-z |